Garcea N, Caruso A, Campo S, Scotto V, Siccardi P
Acta Eur Fertil. 1977 Sep;8(3):229-38.
The authors administrated the Clomiphene, in different doses, to 8 patients among 27 observed. These patients were checked for a long time by basal body temperature and in some cases, measuring total urinary estrogens and pregnandioluria. The therapy was administrated in 38 cicles of the 163 cicles observed. This drug got evident results on flux duration, less significant results on the cicle length. The Clomiphene produced ovulatory cicles in 58 per cent of the cases, against 7 per cent of spontaneous ovulatory cicles of the same patients. The drug effect is better in the cases with normo or moderate hypo or hyper estrogenism, not so good in the cases with a remarcable hypoestrogenism. The therapy with Clomiphene did not produce any inconvenient. The results got were put in comparison with those of the other drug (Ciclophenile) and the superiority of Clomiphene was confirmed.
作者对27名观察对象中的8名患者使用了不同剂量的克罗米芬。通过基础体温对这些患者进行了长期检查，在某些情况下，还测量了尿总雌激素和孕二醇尿。在观察的163个周期中，有38个周期进行了该治疗。该药物在月经周期持续时间上有明显效果，在周期长度上效果不太显著。克罗米芬在58%的病例中产生了排卵周期，而同一患者自发排卵周期的比例为7%。该药物在雌激素水平正常、轻度或中度低下或亢进的病例中效果较好，在雌激素明显低下的病例中效果不佳。使用克罗米芬治疗未产生任何不良反应。将所得结果与另一种药物（环苯丙胺）的结果进行比较，证实了克罗米芬的优越性。
