Green J B, Burba A, Freed D M, Elder W W, Xu W
Edward Hines, Jr. Veterans Hospital, Hines, Illinois 60141, USA.
Alzheimer Dis Assoc Disord. 1997 Sep;11(3):153-7. doi: 10.1097/00002093-199709000-00007.
The P1 component of the middle latency auditory evoked potential (MLAEP) was found to be absent in 47.5% of 101 patients with Alzheimer disease (AD). Lack of a P1 component recently has been associated with a more rapid decline in cognitive performance. The blink reflex (BR) was tested in 36 patients with probable AD and 17 elderly control subjects. All subjects also underwent P1 recording. Patients lacking a P1 potential showed a significant increase in latency of the contralateral R2 response of the BR. The P1 component and the R2 response may differentiate a subgroup of AD patients with involvement of the brainstem, especially the reticular formation.
在101例阿尔茨海默病（AD）患者中，发现47.5%的患者中潜伏期听觉诱发电位（MLAEP）的P1成分缺失。近期研究表明，缺乏P1成分与认知功能的更快衰退有关。对36例可能患有AD的患者和17名老年对照受试者进行了眨眼反射（BR）测试。所有受试者均进行了P1记录。缺乏P1电位的患者BR对侧R2反应的潜伏期显著延长。P1成分和R2反应可能有助于区分AD患者中脑干尤其是网状结构受累的亚组。
