Cara A, Reitz M S
Basic Research Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Leukemia. 1997 Sep;11(9):1395-9. doi: 10.1038/sj.leu.2400776.
During infection with different retroviruses, high levels of unintegrated extrachromosomal DNA accumulate in infected cells. While extrachromosomal linear DNA is the immediate precursor of the integrated provirus, the function, if any, of extrachromosomal circular DNA has been unclear. Several groups have attempted to address the possible function, activity, and importance of this unintegrated DNA during the life cycle of retroviruses and the course of retroviral-associated diseases. This review summarizes recent work in this field and tries to analyze some aspects of extrachromosomal forms of retroviral DNA and their possible application as a molecular biological tool.
在感染不同逆转录病毒期间，未整合的染色体外DNA在受感染细胞中大量积累。虽然染色体外线状DNA是整合前病毒的直接前体，但染色体外环状DNA的功能（如果有）尚不清楚。几个研究小组试图探讨这种未整合DNA在逆转录病毒生命周期和逆转录病毒相关疾病过程中的可能功能、活性及重要性。本综述总结了该领域的最新研究工作，并试图分析逆转录病毒DNA染色体外形式的某些方面及其作为分子生物学工具的可能应用。
