Ligers A, He B, Fogdell-Hahn A, Olerup O, Hillert J
Department of Neurology, Karolinska Institute, Huddinge University Hospital, Sweden.
Eur J Immunogenet. 1997 Aug;24(4):259-64. doi: 10.1111/j.1365-2370.1997.tb00019.x.
Multiple sclerosis (MS) is a demyelinating inflammatory disease of the central nervous system. Autoantibodies are though to participate in the pathogenesis. Previous reports on the role of immunoglobulin (Ig) variable gene segments in MS are contradictory. Here, by using a highly polymorphic variable number tandem repeat (VNTR) marker located in the centre of the IgH chain locus, we demonstrate a lack of linkage and association with MS in 34 multiplex families and 113 sporadic MS patients in Sweden. Stratification for the presence or absence of the MS-associated HLA-Dw2 haplotype did not influence the negative outcome. We conclude that the IgH chain genes are unlikely to play a role in genetic susceptibility to MS in the Swedish population.
多发性硬化症（MS）是一种中枢神经系统的脱髓鞘炎性疾病。自身抗体被认为参与了发病机制。先前关于免疫球蛋白（Ig）可变基因片段在MS中作用的报道相互矛盾。在此，通过使用位于IgH链基因座中心的一个高度多态性的可变数目串联重复序列（VNTR）标记，我们在瑞典的34个多病例家系和113例散发MS患者中证明了其与MS不存在连锁和关联。根据是否存在与MS相关的HLA-Dw2单倍型进行分层，并不影响阴性结果。我们得出结论，在瑞典人群中，IgH链基因不太可能在MS的遗传易感性中起作用。
