经宫颈子宫内膜切除术的激素抑制子宫内膜——一项为期两年随访的前瞻性研究
Hormonal inhibition of endometrium for transcervical endometrial ablation--a prospective study with a 2-year follow-up.
作者信息
Römer T, Schwesinger G
机构信息
Department of Obstetrics and Gynaecology, Ernst-Moritz-Arndt-University, Greifswald, Germany.
出版信息
Eur J Obstet Gynecol Reprod Biol. 1997 Aug;74(2):201-3. doi: 10.1016/s0301-2115(97)00103-6.
OBJECTIVE
To determine the best pretreatment of the endometrium prior to roller ball endometrial ablation.
STUDY DESIGN
Forty patients with recurrent hypermenorrhea underwent diagnostic hysteroscopy and dilation and curettage. They were then assigned to receive either no pretreatment or pretreatment with danazol, a GnRH-analogue, or a gestagen prior to roller ball endometrial ablation. Endometrial suppression was estimated by the surgeon at the time of the procedure, and endometrial biopsies were obtained. Patients were followed for 24 months.
RESULTS
The subjective estimation of the surgeon showed a sufficient pretreatment after danazol or a GnRH-analogue in 90% of the cases. Histological findings correlated with these findings. The highest level of amenorrhoea at 2 years of follow-up was also reached after danazol or GnRH-analogue pretreatment.
CONCLUSIONS
Danazol- or GnRH-analogue should be used for pretreatment prior to endometrial ablation using the roller ball technique.
目的
确定在滚球子宫内膜切除术之前子宫内膜的最佳预处理方法。
研究设计
40例复发性月经过多患者接受了诊断性宫腔镜检查及扩张刮宫术。然后，她们被分配在滚球子宫内膜切除术之前不接受任何预处理，或接受达那唑、促性腺激素释放激素类似物（GnRH类似物）或孕激素进行预处理。手术时由外科医生评估子宫内膜抑制情况，并获取子宫内膜活检样本。对患者进行了24个月的随访。
结果
外科医生的主观评估显示，90%的病例在使用达那唑或GnRH类似物预处理后达到了充分的预处理效果。组织学检查结果与这些发现相关。随访2年时，达那唑或GnRH类似物预处理后闭经程度也最高。
结论
在使用滚球技术进行子宫内膜切除术之前，应使用达那唑或GnRH类似物进行预处理。
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