Toren P, Karasik A, Eldar S, Wolmer L, Shimon I, Weitz R, Inbar D, Koren S, Pariente C, Reiss A, Weizman R, Laor N
Tel Aviv Community Mental Health Center, Tel Aviv University, Israel.
J Psychiatr Res. 1997 May-Jun;31(3):359-63. doi: 10.1016/s0022-3956(96)00061-1.
In view of the recent conflicting findings regarding the causative role of thyroid abnormalities in attention deficit hyperactivity disorder (ADHD), we performed a replication study to clarify the issue and establish clinical guidelines. Thyroid tests were performed in 43 ADHD children and 28 age- and gender-matched controls. Sixteen ADHD children showed total triiodothyronine (TT3) levels which were slightly above the upper limit of normal, but no significant difference in TT3 values was noted between the ADHD and the control groups. Moreover, none of the ADHD subjects had abnormal levels of total thyroxine, free thyroxine, thyroid stimulating hormone or total triiodothyronine reuptake. The present study supplies additional evidence for the lack of an association between thyroid function and ADHD, and counters the suggestion that thyroid function be routinely screened for in ADHD children.
鉴于近期关于甲状腺异常在注意力缺陷多动障碍（ADHD）病因学作用方面存在相互矛盾的研究结果，我们开展了一项重复研究以阐明该问题并制定临床指南。对43名ADHD儿童及28名年龄和性别匹配的对照组儿童进行了甲状腺检查。16名ADHD儿童的总三碘甲状腺原氨酸（TT3）水平略高于正常上限，但ADHD组与对照组之间的TT3值无显著差异。此外，所有ADHD受试者的总甲状腺素、游离甲状腺素、促甲状腺激素或总三碘甲状腺原氨酸摄取水平均无异常。本研究为甲状腺功能与ADHD之间缺乏关联提供了额外证据，反驳了对ADHD儿童常规筛查甲状腺功能的建议。
