Charles N C, Fox D M, Glasberg S S, Sawicki J
Department of Ophthalmology, New York University Medical Center, New York 10016, USA.
Ophthalmology. 1997 Sep;104(9):1454-6. doi: 10.1016/s0161-6420(97)30117-1.
The granular cell tumor (GCT) is a common, usually benign, neoplasm of uncertain histogenesis that may affect any organ in the body. It occurs rarely in ophthalmic sites, where orbital location is most frequent. The purpose of this report is to describe a unique case of an epibulbar, subconjunctival GCT in a child.
Histopathologic examination of the excised tumor included standard and immunohistochemical staining of formaldehyde-fixed, paraffin-embedded tissue.
Histopathologic study showed the characteristic morphology of GCT. Immunohistochemistry was strongly positive for vimentin, weakly and partly positive for neuron-specific enolase, and negative for S-100 and HAM-56.
Granular cell tumor must be added to the differential diagnosis of epibulbar masses. Immunohistochemistry of the tumor in this case suggests an uncommitted mesenchymal cell origin.
颗粒细胞瘤（GCT）是一种常见的、通常为良性的肿瘤，其组织发生尚不明确，可累及身体的任何器官。它在眼部部位很少见，其中眼眶部位最为常见。本报告的目的是描述一例儿童眼球表面、结膜下颗粒细胞瘤的独特病例。
对切除肿瘤进行组织病理学检查，包括对甲醛固定、石蜡包埋组织进行标准染色和免疫组织化学染色。
组织病理学研究显示了颗粒细胞瘤的特征性形态。免疫组织化学检查显示波形蛋白呈强阳性，神经元特异性烯醇化酶呈弱阳性且部分阳性，S-100和HAM-56呈阴性。
颗粒细胞瘤必须列入眼球表面肿物的鉴别诊断。该病例肿瘤的免疫组织化学检查提示其起源于未分化的间充质细胞。
