有证据表明某些8-氨基喹啉是治疗恰加斯病的潜在有效药物。
Evidence that certain 8-aminoquinolines are potentially effective drugs against Chagas disease.
作者信息
Kinnamon K E, Poon B T, Hanson W L, Waits V B
机构信息
Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Washington, DC 20307-5100, USA.
出版信息
Ann Trop Med Parasitol. 1997 Mar;91(2):147-52. doi: 10.1080/00034983.1997.11813124.
Forty 8-aminoquinolines (a chemical class with members having some activity against Trypanosoma cruzi infections) were evaluated for their effectiveness in reducing the 14-day parasitaemias of 4-6 week-old, female, albino mice infected with a Brazilian strain of T. cruzi. Six of the compounds were more active or as active as the reference drug, nifurtimox, and one was > 13-fold as efficacious. Certain members of the series tested warrant further evaluation.
对40种8-氨基喹啉（这是一类对克氏锥虫感染具有一定活性的化学物质）进行了评估，以确定它们在降低感染巴西克氏锥虫株的4至6周龄雌性白化小鼠14天内寄生虫血症方面的有效性。其中六种化合物的活性比参考药物硝呋莫司更高或与之相当，还有一种化合物的效力比硝呋莫司高13倍以上。该系列中测试的某些化合物值得进一步评估。
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