[硝呋替莫作为预防药物用于预防因相关疾病接受皮质类固醇治疗的慢性恰加斯病患者病情复发]

[Nifurtimox as a prophylactic drug to prevent reactivation in chronic chagasic patients treated with corticoid for associated diseases].

作者信息

Rassi A, Neto V A, de Siqueira A F, Leite M S

机构信息

Departamento de Clínica Médica, Faculdade de Medicina, Universidade Federal de Goiás, Brasil.

出版信息

Rev Soc Bras Med Trop. 1998 May-Jun;31(3):249-55. doi: 10.1590/s0037-86821998000300001.

DOI:10.1590/s0037-86821998000300001

PMID:9612015

Abstract

Patients in the chronic phase of Chagas' disease and receiving corticoid because of concommitant diseases were treated with nifurtimox. We proved in another paper that in the chronic phase of Chagas' disease corticoid use is associated with increased parasitemia, as evaluated by xenodiagnosis. In this study nifurtimox use prevented this increase, and we suggest that in immunocompromised patients with chronic Chagas' disease the use of this drug could be useful.

摘要

恰加斯病慢性期且因并发疾病正在接受皮质类固醇治疗的患者，接受了硝呋替莫治疗。我们在另一篇论文中证明，在恰加斯病慢性期，如通过异种接种诊断评估，使用皮质类固醇与寄生虫血症增加有关。在本研究中，使用硝呋替莫可防止这种增加，我们建议在免疫功能低下的慢性恰加斯病患者中使用这种药物可能会有帮助。