Markopoulos A K, Antoniades D, Papanayotou P, Trigonidis G
Aristotle University of Thessaloniki, School of Dentistry, Department of Oral Medicine/Pathology, Greece.
Oral Oncol. 1997 Jul;33(4):263-9. doi: 10.1016/s0964-1955(97)00005-5.
326 patients with oral lichen planus were followed for periods ranging from 6 months to 10 years (mean 4.8 years), in an attempt to clarify the malignant potential of this disease which is still controversial. Malignant transformation occurred in 4 patients (1.3%) in a mean time of 6.5 years after the onset of lichen planus. Before cancer development, 3 of these patients manifested the erosive form of oral lichen planus, while the others, a combination of the papular/atrophic form. Malignant transformation in our patients could not be associated with any evident factors, such as family history, local irritation, alcohol consumption, nutritional disturbances or other systemic diseases.
对326例口腔扁平苔藓患者进行了为期6个月至10年（平均4.8年）的随访，以试图阐明这种仍存在争议的疾病的恶变潜能。4例患者（1.3%）发生恶变，恶变平均发生在扁平苔藓发病后6.5年。在发生癌变前，其中3例患者表现为糜烂型口腔扁平苔藓，而其他患者则为丘疹/萎缩型。我们的患者发生恶变与任何明显因素无关，如家族史、局部刺激、饮酒、营养紊乱或其他全身性疾病。
