Yang C M, Chen M S, Tsou Yau K I, Teng R J
Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan ROC.
J Formos Med Assoc. 1997 Sep;96(9):734-9.
Both cryotherapy and laser photocoagulation have been advocated for the treatment of stage III retinopathy of prematurity (ROP). In this retrospective study, we looked at which treatment was more effective and caused fewer complications. The outcomes of 23 patients (45 eyes) with stage III ROP treated with transconjunctival cryotherapy or indirect diode laser photocoagulation were reviewed. Group 1 (10 patients, 20 eyes) received cryotherapy and group 2 (13 patients, 25 eyes) received photocoagulation. In group 1, all had progressive ROP and one patient had bilateral neovascularization involving zone I. After treatment, 17 eyes had regression of ROP with good anatomic results, one eye had regression of the disease with mild to moderate macular ectopia and vessel traction, and two eyes (one patient) with zone I involvement advanced to stage V in 2 weeks. In group 2, 12 patients had threshold ROP, two had neovascularization involving zone I, and one patient had prethreshold zone I ROP. After treatment, 24 eyes had regression of ROP with good anatomic results and one eye had mild ectopic macula. Two eyes received two sessions of treatment. The results suggest that photocoagulation is at least as effective as cryotherapy and may be a favorable alternative for zone I ROP.
冷冻疗法和激光光凝术都被推荐用于治疗Ⅲ期早产儿视网膜病变（ROP）。在这项回顾性研究中，我们观察了哪种治疗方法更有效且并发症更少。对23例（45只眼）接受经结膜冷冻疗法或间接二极管激光光凝术治疗的Ⅲ期ROP患者的治疗结果进行了回顾。第1组（10例患者，20只眼）接受冷冻疗法，第2组（13例患者，25只眼）接受光凝术。在第1组中，所有患者均为进展性ROP，1例患者双眼新生血管累及I区。治疗后，17只眼ROP消退，解剖结果良好，1只眼疾病消退，但有轻度至中度黄斑异位和血管牵拉，2只眼（1例患者）累及I区，在2周内进展为V期。在第2组中，12例患者为阈值ROP，2例患者新生血管累及I区，1例患者为阈值前I区ROP。治疗后，24只眼ROP消退，解剖结果良好，1只眼有轻度黄斑异位。2只眼接受了两个疗程的治疗。结果表明，光凝术至少与冷冻疗法一样有效，对于I区ROP可能是一种更好的选择。
