van Mourik J, Weerdenburg H
Department of Orthopedics, Sint Joseph Ziakenhuis, Valdhoven, The Netherlands.
AJR Am J Roentgenol. 1997 Oct;169(4):1105-8. doi: 10.2214/ajr.169.4.9308472.
This study investigated the diagnostic value of radiographic anthropometry in patients with multiple epiphyseal dysplasia (MED).
In 15 children of one family with MED (12 affected, three unaffected), all of whom were less than 16 years old, measurements were made of the distal femoral metaphysis and epiphysis on standard anteroposterior radiographs of the knee. In each individual, the height of the epiphysis was plotted against the width of both the epiphysis and the metaphysis. Sensitivity, specificity, and positive and negative predictive values were calculated.
In 11 of 12 children with MED, the plotted values were more than 2 SDs below the mean. Sensitivity was 92%, specificity was 100%, and positive predictive value was 100%.
Anthropometry is useful to detect involvement of a child in a family with MED. For this particular family, anthropometry had a high positive predictive value.
本研究调查了放射学人体测量学在多发性骨骺发育不良（MED）患者中的诊断价值。
在一个患有MED的家庭中的15名儿童（12名患病，3名未患病）中，所有儿童年龄均小于16岁，在标准的膝关节前后位X线片上对股骨远端干骺端和骨骺进行测量。在每个个体中，将骨骺的高度与骨骺和干骺端的宽度进行绘图。计算敏感性、特异性以及阳性和阴性预测值。
在12名患有MED的儿童中，有11名的绘图值低于平均值2个标准差以上。敏感性为92%，特异性为100%，阳性预测值为100%。
人体测量学有助于检测患有MED家庭中儿童的受累情况。对于这个特定的家庭，人体测量学具有较高的阳性预测值。
