Orengo I F, Salasche S J, Fewkes J, Khan J, Thornby J, Rubin F
Harvard Medical School, Boston, Massachusetts, USA.
J Am Acad Dermatol. 1997 Sep;37(3 Pt 1):395-7. doi: 10.1016/s0190-9622(97)70138-5.
Certain histologic subtypes of basal cell carcinoma (BCC) behave more aggressively and require more aggressive treatment.
The aim of this study was to see whether certain subtypes of BCC require more Mohs stages to achieve tumor-free margins.
A retrospective study of 342 primary BCCs treated with Mohs micrographic surgery (MMS) was performed identifying the histologic subtype of BCC present and the number of stages required to clear the tumor.
The aggressive subtypes (infiltrative, morpheaform, micronodular, and mixed) were most frequently found when high numbers of Mohs stages were required for cure.
The more aggressive subtypes of BCC require more MMS stages to achieve tumor-free margins, which is consistent with the concept that these subtypes usually require more aggressive treatment from the start.
基底细胞癌（BCC）的某些组织学亚型表现更为侵袭性，需要更积极的治疗。
本研究的目的是观察某些BCC亚型是否需要更多的莫氏分期来达到无肿瘤切缘。
对342例接受莫氏显微外科手术（MMS）治疗的原发性BCC进行回顾性研究，确定存在的BCC组织学亚型以及清除肿瘤所需的分期数。
当治愈需要大量莫氏分期时，最常发现侵袭性亚型（浸润性、硬斑病样、微结节性和混合型）。
BCC的侵袭性越强的亚型需要更多的MMS分期来达到无肿瘤切缘，这与这些亚型通常从一开始就需要更积极治疗的概念一致。
