Cavallo R, Rubenstein D, Peifer M
Department of Dermatology, University of North Carolina at Chapel Hill 27599-3280, USA.
Curr Opin Genet Dev. 1997 Aug;7(4):459-66. doi: 10.1016/s0959-437x(97)80071-8.
Within the past year, Armadillo and beta-catenin's role in transducing the Wingless/Wnt signal has been substantially clarified. It is now clear that Armadillo and beta-catenin bind directly to members of the T-cell factor/lymphoid enhancer factor subfamily of HMG box DNA-binding proteins, forming bipartite transcription factors that regulate Wingless/Wnt responsive genes in both Drosophila and vertebrates. These partners not only play key roles in a variety of cell fate decisions during normal development but, when inappropriately activated, contribute to both colon cancer and melanoma.
在过去的一年里，犰狳蛋白和β-连环蛋白在转导无翅型/翼状螺旋转录因子（Wingless/Wnt）信号中的作用已基本明确。现在已经清楚，犰狳蛋白和β-连环蛋白直接与HMG盒DNA结合蛋白的T细胞因子/淋巴样增强子因子亚家族成员结合，形成二元转录因子，在果蝇和脊椎动物中调节无翅型/翼状螺旋转录因子（Wingless/Wnt）反应性基因。这些蛋白不仅在正常发育过程中的各种细胞命运决定中起关键作用，而且在被不适当激活时，会导致结肠癌和黑色素瘤。
