肢体发育中Hox基因的遗传相互作用：从复合突变体中学习

Genetic interactions of Hox genes in limb development: learning from compound mutants.

作者信息

Rijli F M, Chambon P

机构信息

Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, Collège de France, Illkirch, France.

出版信息

Curr Opin Genet Dev. 1997 Aug;7(4):481-7. doi: 10.1016/s0959-437x(97)80074-3.

DOI:10.1016/s0959-437x(97)80074-3

PMID:9309178

Abstract

The recent generation of mice harboring multiple mutations in Hox genes has highlighted the role of these genes in controlling growth and patterning of the limb bud. The study of the phenotypes has not only revealed a complex network of genetic interactions among paralogous and non-paralogous Abdominal-B-related Hox genes but has also refined our understanding of their function.

摘要

最近一代在Hox基因中携带多个突变的小鼠突出了这些基因在控制肢芽生长和模式形成中的作用。对这些表型的研究不仅揭示了同源和非同源的腹部B相关Hox基因之间复杂的遗传相互作用网络，还完善了我们对它们功能的理解。