Yamaguchi T P
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
Curr Opin Genet Dev. 1997 Aug;7(4):513-8. doi: 10.1016/s0959-437x(97)80079-2.
Understanding how muscles and the skeleton develop is essential to understanding how distinct form arises in different vertebrate organisms. The meristic somites give rise to the serially-repeated precursors of the axial skeleton and musculature. Recent studies of somitogenesis have shed light upon the mechanisms of segmentation in vertebrates and the relationship between segmentation and patterning. Significant advances have also been made in connecting signalling molecules that possess somite patterning activity with downstream effector genes.
了解肌肉和骨骼如何发育对于理解不同脊椎动物机体中独特形态的形成至关重要。分节的体节产生了轴向骨骼和肌肉组织的一系列重复前体。最近关于体节发生的研究揭示了脊椎动物的分节机制以及分节与模式形成之间的关系。在将具有体节模式形成活性的信号分子与下游效应基因联系起来方面也取得了重大进展。
