Murray D, Ben-Tal N, Honig B, McLaughlin S
Department of Physiology and Biophysics, SUNY Stony Brook 11794-8661, USA.
Structure. 1997 Aug 15;5(8):985-9. doi: 10.1016/s0969-2126(97)00251-7.
Cell membrane association by several important peripheral proteins, such as Src, MARCKS, HIV-1 Gag, and K-Ras, requires nonspecific electrostatic interactions between a cluster of basic residues on the protein and acidic phospholipids in the plasma membrane. A simple theoretical model based on the nonlinear Poisson-Boltzmann equation describes well the experimentally measured electrostatic association between such proteins and the cell membrane.
几种重要的外周蛋白，如Src、MARCKS、HIV-1 Gag和K-Ras与细胞膜的结合，需要蛋白质上一簇碱性残基与质膜中酸性磷脂之间的非特异性静电相互作用。基于非线性泊松-玻尔兹曼方程的一个简单理论模型很好地描述了此类蛋白质与细胞膜之间实验测量的静电结合。
