Papageorgiou A C, Acharya K R
Department of Biology and Biochemistry, University of Bath, United Kingdom.
Structure. 1997 Aug 15;5(8):991-6. doi: 10.1016/s0969-2126(97)00252-9.
Superantigens interact with major histocompatibility complex (MHC) class II molecules and T-cell receptors (TcRs) forming a trimolecular complex which is able to induce proliferation and cytokine production in T cells. Although superantigens appear to act through a common mechanism, they very in many of their specific interactions and biological properties. X-ray crystallographic studies and biochemical experiments have now established that cross-linking of MHC class II molecules and the TcR by superantigens can occur in a number of different modes.
超抗原与主要组织相容性复合体（MHC）II类分子和T细胞受体（TcR）相互作用，形成一个三分子复合物，该复合物能够诱导T细胞增殖并产生细胞因子。尽管超抗原似乎通过一种共同机制发挥作用，但它们在许多特定相互作用和生物学特性方面存在差异。X射线晶体学研究和生化实验现已证实，超抗原对MHC II类分子和TcR的交联可以通过多种不同方式发生。
