Pasqualetti P, Casale R
Department of Internal Medicine and Public Health, School of Medicine and Surgery, University of L'Aquila, Italy.
Biomed Pharmacother. 1997;51(6-7):284-5. doi: 10.1016/S0753-3322(97)83544-5.
A case of monoclonal gammopathy of undetermined significance (MGUS) which evolved directly into primary plasma cell leukemia (PCL) is reported. Even if MGUS and PCL represent the opposite aspects of the same immunoproliferative disorder, no previous cases of this direct evolution have been described, as stated by an accurate review of the specific literature. The patient abruptly developed PCL after five months from the discovery of a serum monoclonal spike, without any other clinical, laboratory and radiological abnormalities. The practical conclusions of this case report indicate that a patient with MGUS must be followed periodically and over an indefinite period, and that PCL must be considered into the possible evolution of MGUS.
本文报告了一例意义未明的单克隆丙种球蛋白病（MGUS）直接演变为原发性浆细胞白血病（PCL）的病例。尽管MGUS和PCL代表了同一免疫增殖性疾病的相反方面，但正如对特定文献的精确回顾所述，此前尚无这种直接演变的病例描述。该患者在发现血清单克隆峰后的五个月突然发展为PCL，无任何其他临床、实验室及影像学异常。本病例报告的实际结论表明，MGUS患者必须定期且长期随访，并且PCL必须被视为MGUS可能的演变情况。
