Dumesic D A, Herrmann R R, O'Brien A M
Mayo Clinic, Rochester, Minnesota.
Int J Fertil Womens Med. 1997 Jul-Aug;42(4):255-60.
Hyperandrogenic anovulation is the principal risk factor for non-insulin-dependent diabetes mellitus (NIDDM) in young women. Since many of these women undergo depilatory therapy, the purpose of this study was to estimate the probability of undiagnosed glucose intolerance associated with hyperandrogenic anovulation among premenopausal women requesting electrolysis.
Case-series study.
Women (N = 791) attending one of 27 electrology clinics in the United States, Canada and Germany received questionnaires requesting anthropometric data; personal information regarding age, surgery and medication use, and family histories of excess hair growth in female relatives and diabetes in parents or siblings.
Of 652 respondents less than age 50 years, 643 (98.6%) women had hirsutism, of whom 465 had regular menstrual cycles. One hundred seventy-eight (27.3%) women less than 50 years of age had hirsutism with irregular menses, and one-half of these women also were obese. Regardless of adiposity, one-third of hirsute women with menstrual irregularity knew the cause of their androgen excess, while the remaining two-thirds were unaware of the reason for their excess hair growth.
Assuming a 20% risk of glucose intolerance in obese hyperandrogenic anovulatory women by the fourth decade of life, the estimated prevalence of undiagnosed glucose intolerance from hyperandrogenic anovulation is 1.7% among women requesting electrolysis before age 50 years.
高雄激素性无排卵是年轻女性非胰岛素依赖型糖尿病（NIDDM）的主要危险因素。由于这些女性中有许多人接受脱毛治疗，本研究的目的是估计在要求进行电解脱毛的绝经前女性中，与高雄激素性无排卵相关的未诊断出的糖耐量异常的概率。
病例系列研究。
在美国、加拿大和德国的27家电解脱毛诊所之一就诊的女性（N = 791）收到了问卷，问卷要求提供人体测量数据；有关年龄、手术和用药情况的个人信息，以及女性亲属多毛症家族史和父母或兄弟姐妹糖尿病家族史。
在652名年龄小于50岁的受访者中，643名（98.6%）女性有多毛症，其中465名月经周期规律。178名（27.3%）年龄小于50岁的女性有多毛症且月经不规律，其中一半女性也肥胖。无论肥胖程度如何，月经不规律的多毛女性中有三分之一知道其雄激素过多的原因，而其余三分之二则不知道自己多毛的原因。
假设肥胖的高雄激素性无排卵女性到40岁时糖耐量异常的风险为20%，那么在50岁之前要求进行电解脱毛的女性中，由高雄激素性无排卵导致的未诊断出的糖耐量异常的估计患病率为1.7%。
