Inoue H, Aizawa H, Matsumoto K, Shigyo M, Takata S, Hara M, Hara N
Research Institute for Diseases of the Chest, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Am J Respir Crit Care Med. 1997 Sep;156(3 Pt 1):723-7. doi: 10.1164/ajrccm.156.3.9606019.
beta 2-adrenergic agonists exhibit antipermeability effects in the airways. However, it is not known whether beta 2-agonists have this beneficial effect in airway mucosa that is already inflamed. We evaluated the effects of two inhaled beta 2-agonists, salbutamol and formoterol, on the histamine-induced bronchoconstriction and plasma extravasation in the airways of guinea pigs with or without ozone exposure. Total pulmonary resistance (RL) was measured before and after histamine inhalation in anesthetized animals that were pretreated with inhaled salbutamol, formoterol, or saline. Plasma extravasation in the airways was measured using Evans blue dye. In the control animals not exposed to ozone, salbutamol and formoterol each significantly reduced both the histamine-induced bronchoconstriction and the plasma extravasation in the trachea and main bronchi. In the ozone-exposed animals, the increase in RL after histamine was greater than that in control animals. Salbutamol and formoterol each significantly reduced histamine-induced bronchoconstriction, even in the ozone-exposed animals. Salbutamol did not affect the histamine-induced plasma extravasation, whereas formoterol reduced the plasma extravasation in the main bronchi, but not in the trachea, of the animals exposed to ozone. These results suggest that the anti-inflammatory properties of formoterol in inflamed airways may contribute to the beneficial effects in the treatment of airway inflammation.
β2肾上腺素能激动剂在气道中具有抗通透性作用。然而，尚不清楚β2激动剂在已发炎的气道黏膜中是否具有这种有益作用。我们评估了两种吸入性β2激动剂沙丁胺醇和福莫特罗对组胺诱导的豚鼠气道支气管收缩和血浆外渗的影响，这些豚鼠有或没有暴露于臭氧环境。在麻醉的动物中，在吸入组胺之前和之后测量总肺阻力（RL），这些动物预先吸入了沙丁胺醇、福莫特罗或生理盐水。使用伊文思蓝染料测量气道中的血浆外渗。在未暴露于臭氧的对照动物中，沙丁胺醇和福莫特罗均显著降低了组胺诱导的支气管收缩以及气管和主支气管中的血浆外渗。在暴露于臭氧的动物中，组胺作用后RL的增加大于对照动物。即使在暴露于臭氧的动物中，沙丁胺醇和福莫特罗也均显著降低了组胺诱导的支气管收缩。沙丁胺醇不影响组胺诱导的血浆外渗，而福莫特罗降低了暴露于臭氧的动物主支气管中的血浆外渗，但气管中未降低。这些结果表明，福莫特罗在发炎气道中的抗炎特性可能有助于其在气道炎症治疗中的有益作用。
