Bardi G, Parada L A, Bomme L, Pandis N, Willén R, Johansson B, Jeppsson B, Beroukas K, Heim S, Mitelman F
Department of Clinical Genetics, University Hospital, Lund, Sweden.
Br J Cancer. 1997;76(6):765-9. doi: 10.1038/bjc.1997.459.
Thirty tumorous lesions from seven patients with colorectal cancer were short-term cultured and cytogenetically analysed: 16 non-adenomatous polyps, six adenomas, seven carcinomas, including one in polyp, and one lymph node metastasis. Clonal chromosome aberrations were found in 20 samples in 100% of the carcinomas, in 100% of the adenomas and in 37.5% of the non-adenomatous polyps, i.e. all ten lesions with a normal karyotype were histologically diagnosed as hyperplastic polyps. Although adenomas and carcinomas shared several karyotypic features, two chromosome aberrations, der(8;17)(q10;q10) and -14, were found in carcinomas but not in adenomas, indicating that they might be specifically associated with carcinoma development in the large bowel mucosa. The karyotypic similarity seen between the malignant and benign tumours in the same patient, and also sometimes among non-malignant polyps in the same case, indicates that these microscopically distinct lesions may be part of a single neoplastic clonal expansion.
对7例结直肠癌患者的30个肿瘤性病变进行了短期培养和细胞遗传学分析：16个非腺瘤性息肉、6个腺瘤、7个癌（包括息肉内的1个癌）和1个淋巴结转移灶。在100%的癌、100%的腺瘤和37.5%的非腺瘤性息肉的20个样本中发现了克隆性染色体畸变，即所有10个核型正常的病变在组织学上均被诊断为增生性息肉。虽然腺瘤和癌有几个核型特征相同，但在癌中发现了两个染色体畸变，即der(8;17)(q10;q10)和-14，而在腺瘤中未发现，这表明它们可能与大肠黏膜癌的发生有特异性关联。同一患者的恶性和良性肿瘤之间，以及同一病例的非恶性息肉之间有时所见的核型相似性，表明这些在显微镜下不同的病变可能是单个肿瘤性克隆扩增的一部分。
