伯纳特柯克斯体分离株的致病性与巨噬细胞感染增强因子（Cbmip）和传感器样蛋白（qrsA）基因序列之间的关系

Relationship between pathogenicity of Coxiella burnetii isolates and gene sequences of the macrophage infectivity potentiator (Cbmip) and sensor-like protein (qrsA).

作者信息

Masuzawa T, Sawaki K, Nagaoka H, Akiyama M, Hirai K, Yanagihara Y

机构信息

Department of Microbiology, School of Pharmaceutical Sciences, University of Shizuoka, Japan.

出版信息

FEMS Microbiol Lett. 1997 Sep 15;154(2):201-5. doi: 10.1111/j.1574-6968.1997.tb12644.x.

DOI:10.1111/j.1574-6968.1997.tb12644.x

PMID:9311117

Abstract

Coxiella burnetii, the Q fever agent, is an obligate intracellular bacterium and survival in phagolysosomes is an important virulence factor. The present study was performed to determine the relationship between its pathogenicity and genes related to its survival in macrophages, i.e. macrophage infectivity potentiator and Q fever agent regulatory sensor-like protein. The sequence similarity was more than 99% among Japanese, European and American strains, and no relationship was found between pathogenicity in guinea pigs and these genes.

摘要

伯纳特立克次体是Q热病原体，是一种专性细胞内细菌，在吞噬溶酶体中存活是一个重要的毒力因子。本研究旨在确定其致病性与巨噬细胞内存活相关基因（即巨噬细胞感染增强因子和Q热病原体调节传感器样蛋白）之间的关系。日本、欧洲和美国菌株之间的序列相似性超过99%，且在豚鼠中的致病性与这些基因之间未发现关联。