Tabata M, Amemiya Y, Muroi K, Takahashi H, Tsunoda J, Izumi T, Suzuki T, Komatsu N, Yoshida M, Hatake K, Miura Y
Division of Hematology, Jichi Medical School.
Rinsho Ketsueki. 1997 Aug;38(8):689-95.
A 24-year-old male was admitted to our hospital, complaining of right back pain, in May 1995. Chest X-ray films showed an abnormal mass in the mediastinum. Computed tomography revealed massive effusion in the pleural and pericardial space. A biopsy specimen of the pleural lesion demonstrated lymphoblastic lymphoma of T cell type. After the completion of intensive chemotherapy by our original protocol, he entered into partial remission. Peripheral blood stem cells (PBSC) were harvested using a high-dose cytarabine (Ara-C) followed by granulocyte-colony stimulating factor (G-CSF) mobilization regimen. The total number of collected PBSC was enough to perform two courses of PBSCT. In January 1996, following the conditioning regimen of nimustine hydrochloride, etoposide (VP-16), Ara-C, thiotepa, he received PBSCT. Complete remission was achieved after the 1st PBSCT. In March 1996, he received the 2nd PBSCT following the conditioning regimen of carboplatin, VP-16, ifosfamide. No regimen-related toxity or delayed engrafment was observed. Subsequently, he received irradiation to his neck and mediastinum, the primary site of the disease. As of February 1997, he has no evidence of the disease.
1995年5月，一名24岁男性因右背部疼痛入院。胸部X线片显示纵隔有异常肿块。计算机断层扫描显示胸膜和心包腔有大量积液。胸膜病变的活检标本显示为T细胞型淋巴母细胞淋巴瘤。按照我们最初的方案完成强化化疗后，他进入部分缓解期。使用大剂量阿糖胞苷（Ara-C）联合粒细胞集落刺激因子（G-CSF）动员方案采集外周血干细胞（PBSC）。采集的PBSC总数足以进行两个疗程的PBSCT。1996年1月，在接受盐酸尼莫司汀、依托泊苷（VP-16）、阿糖胞苷、噻替派的预处理方案后，他接受了PBSCT。第1次PBSCT后实现了完全缓解。1996年3月，在接受卡铂、VP-16、异环磷酰胺的预处理方案后，他接受了第2次PBSCT。未观察到与方案相关的毒性反应或延迟植入。随后，他接受了颈部和纵隔（疾病原发部位）的放疗。截至1997年2月，他没有疾病证据。
