Gálvez Gudiño V J
Hospital del ISSSTE, San Luis Potosi, SLP, México, DF.
Rev Alerg Mex. 1993 Sep-Oct;40(5):132-4.
A cortisol curve was practiced on 32 healthy persons with an average age of 38.7 years, being the morning amount at 8 o'clock of 10 mg/100 ml o higher. Later we practiced the same study in 42 patients with an average age of 41.4 years, that were under a corticosteroid therapy higher than 10 mg per day of prednisone during more than three months of an uninterrupted prescription and said treatment was stopped 48 previous hours to the study. We found that 27 of them (64.2%) had lowe morning amount of cortisol to those of the control group, and the patients with rheumatoid arthritis being the lowest. It is concluded that the type of systemic disease could be another factor in the suppression of the axis H-H-A of patients under a higher dosis than 10 mg of prednisone and a durability longer than three continuous months.
对32名平均年龄为38.7岁的健康人进行了皮质醇曲线检测，8点时的早晨皮质醇量为10毫克/100毫升或更高。后来，我们对42名平均年龄为41.4岁的患者进行了同样的研究，这些患者接受了超过三个月不间断处方的每天高于10毫克泼尼松的皮质类固醇治疗，并且在研究前48小时停止了该治疗。我们发现其中27人（64.2%）的早晨皮质醇量低于对照组，类风湿性关节炎患者的皮质醇量最低。得出的结论是，对于接受高于10毫克泼尼松剂量且持续时间超过三个月的患者，全身性疾病的类型可能是抑制下丘脑-垂体-肾上腺（H-H-A）轴的另一个因素。
