Salvemini D
Discovery Pharmacology, G.D. Searle Co., St. Louis, Missouri 63167, USA.
Cell Mol Life Sci. 1997 Jul;53(7):576-82. doi: 10.1007/s000180050074.
Nitric oxide (NO), derived from L-arginine (L-Arg) by the enzyme nitric oxide synthase (NOS) is involved in the regulation of several important physiological and pathophysiological functions. The mechanisms by which NO exerts some of its beneficial or detrimental effects include activation of guanylate cyclase, formation of peroxynitrite, apoptosis, and regulation of cyclooxygenase (COX). Cyclooxygenase (COX) is the enzyme that converts arachidonic acid to prostaglandins (PG), prostacyclin (PGI2) and thromboxane A2. The role of NO in the regulation of COX and its importance in physiology, pathology and therapy will be reviewed. Evidence will be presented to suggest that COX enzymes are targets for the physiopathological roles of NO and that once activated in the presence of NO, they represent important transduction mechanisms for its multifaceted actions.
一氧化氮（NO）由一氧化氮合酶（NOS）作用于L-精氨酸（L-Arg）产生，参与多种重要生理和病理生理功能的调节。NO发挥其有益或有害作用的机制包括激活鸟苷酸环化酶、形成过氧亚硝酸盐、诱导细胞凋亡以及调节环氧化酶（COX）。环氧化酶（COX）可将花生四烯酸转化为前列腺素（PG）、前列环素（PGI2）和血栓素A2。本文将综述NO在COX调节中的作用及其在生理、病理和治疗方面的重要性。有证据表明，COX酶是NO生理病理作用的靶点，并且一旦在有NO的情况下被激活，它们就代表了NO多方面作用的重要转导机制。
