Olmos L
Ann Dermatol Venereol. 1977 Aug-Sep;104(8-9):538-41.
The application of an alcoholic solution of podophyllin resin at concentrations above 10 p. 100 on guinea-pig udders, produces in epidemic Langerhans cells the same cytological effects as those by colchicine and vinca alcaloid in culture cells. The Langerhans cells are a suitable experimental model in vivo because of its easy ultrastructural identification, its migratory character and its preferential localization in epidermis.
将浓度高于10%的鬼臼树脂酒精溶液涂抹于豚鼠乳房，会使表皮郎格汉斯细胞产生与秋水仙碱和长春花生物碱作用于培养细胞时相同的细胞学效应。郎格汉斯细胞是一种合适的体内实验模型，因为其易于进行超微结构鉴定，具有迁移特性，且优先定位在表皮。
