Pinto A, Corrao S, Galati D, Arnone S, Licata A, Parrinello G, Maniscalchi T, Licata G
Institute of Internal Medicine, University of Palermo, Italy.
Angiology. 1997 Sep;48(9):805-11. doi: 10.1177/000331979704800907.
Thirty adult patients with distal, monolateral deep vein thrombosis of the lower limbs were randomly treated for sixty days either with subcutaneous Ca-Heparin or with Sulodexide, administered IM for ten days and orally for fifty days. The thrombus accretion above the knee, the venous pressures of the affected leg, the clinical symptomatology, and some laboratory coagulative tests were monitored throughout the administration period. Local tolerability of the two treatments was also evaluated. The two applied treatments evidenced a net antithrombotic activity, preventing thrombus accretion above the knee, improving with the same efficacy the venous pressures in the affected legs, and similarly reducing clinical symptoms, with a quick and statistically significant trend toward normalization. Blood fibrinogen was significantly lowered by both drugs, while only Ca-heparin yielded a prolongation of activated partial thromboplastin time. Local tolerability of treatments was better for the mainly oral Sulodexide administrations, while subcutaneous Ca-heparin often induced small, though transient, hematomas.
30例成年下肢远端单侧深静脉血栓形成患者被随机分为两组，分别接受皮下注射钙肝素或舒洛地昔治疗60天。舒洛地昔先肌内注射10天，后口服50天。在整个给药期间，监测膝上血栓增大情况、患侧腿部静脉压力、临床症状以及一些实验室凝血试验。同时评估两种治疗方法的局部耐受性。两种治疗方法均显示出明显的抗血栓活性，可防止膝上血栓增大，以相同疗效改善患侧腿部静脉压力，并同样减轻临床症状，且有迅速且具有统计学意义的恢复正常趋势。两种药物均显著降低血纤维蛋白原，而只有钙肝素使活化部分凝血活酶时间延长。主要为口服给药的舒洛地昔治疗的局部耐受性较好，而皮下注射钙肝素常引起小的、虽为短暂性的血肿。
