Waurick R, Bone H G, Meyer J, Booke M, Meissner A, Prien T, Van Aken H
Department of Anaesthesiology and Operative Intensive Care Medicine, Westfälische-Wilhelms-Universität, Münster, Germany.
Eur J Pharmacol. 1997 Aug 27;333(2-3):181-6. doi: 10.1016/s0014-2999(97)01132-1.
Chronically instrumented awake healthy sheep (n = 6) received the synthetic catecholamine, dopexamine, during or without a background infusion of the nitric oxide synthase inhibitor. L-nitro-arginine-methylester (L-NAME). Three days later, hypotensive-hyperdynamic circulation was induced and maintained by continuous infusion of Salmonella typhosa endotoxin (10 ng/kg per min). After 24 h of continuous endotoxin infusion, the dopexamine L-NAME protocol was repeated. In healthy and endotoxaemic animals with and without nitric oxide synthase inhibition dopexamine caused the same haemodynamic changes: heart rate and cardiac output increased, mean arterial pressure and systemic vascular resistance decreased. L-NAME infusion induced normalisation of the hypotonic-hyperdynamic circulation in endotoxaemic animals. Dopexamine reduced some adverse effects of L-NAME treatment, like increased pulmonary vascular resistance and decreased oxygen delivery. In conclusion the haemodynamic effects of dopexamine are independent of the amount of nitric oxide production. Dopexamine may attenuate some of the adverse effects of nitric oxide synthase inhibition.
对长期植入仪器的清醒健康绵羊（n = 6）在给予一氧化氮合酶抑制剂L-硝基精氨酸甲酯（L-NAME）进行背景输注期间或未进行背景输注时给予合成儿茶酚胺多培沙明。三天后，通过持续输注鼠伤寒沙门氏菌内毒素（每分钟10 ng/kg）诱导并维持低血压-高动力循环。在持续输注内毒素24小时后，重复多培沙明-L-NAME方案。在有或没有一氧化氮合酶抑制的健康和内毒素血症动物中，多培沙明引起相同的血流动力学变化：心率和心输出量增加，平均动脉压和全身血管阻力降低。L-NAME输注使内毒素血症动物的低渗-高动力循环恢复正常。多培沙明减轻了L-NAME治疗的一些不良反应，如肺血管阻力增加和氧输送减少。总之，多培沙明的血流动力学效应与一氧化氮产生量无关。多培沙明可能减轻一氧化氮合酶抑制的一些不良反应。
