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必需淋巴细胞功能相关蛋白1（LFA-1）：通过Fas/APO-1/CD95介导T细胞诱导B细胞凋亡的细胞间黏附分子相互作用

Essential lymphocyte function associated 1 (LFA-1): intercellular adhesion molecule interactions for T cell-mediated B cell apoptosis by Fas/APO-1/CD95.

作者信息

Wang J, Lenardo M J

机构信息

Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-1892, USA.

出版信息

J Exp Med. 1997 Oct 6;186(7):1171-6. doi: 10.1084/jem.186.7.1171.

DOI:10.1084/jem.186.7.1171
PMID:9314566
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2199075/
Abstract

B cells are susceptible to Fas ligand (FasL)+ CD4(+) Th1 cell-mediated apoptosis. We demonstrate that blocking the interactions between lymphocyte function associated (LFA)-1 and intercellular adhesion molecule(ICAM)-1 and ICAM-2 completely suppresses Fas-dependent B cell lysis. Antibodies to CD2 and CD48 partially suppress B cell apoptosis, whereas anti-B7.1 and anti-B7.2 antibodies have no effect. Also, B cells from ICAM-1-deficient mice are resistant to FasL+ T cell-mediated death. Our results suggest that LFA-1/ICAM interactions are crucial for Th1 cell-mediated B cell apoptosis and may contribute to the maintenance of B cell homeostasis in vivo.

摘要

B细胞易受Fas配体（FasL）+ CD4（+）Th1细胞介导的凋亡影响。我们证明，阻断淋巴细胞功能相关抗原-1（LFA-1）与细胞间黏附分子-1（ICAM-1）和ICAM-2之间的相互作用可完全抑制Fas依赖的B细胞裂解。抗CD2和抗CD48抗体可部分抑制B细胞凋亡，而抗B7.1和抗B7.2抗体则无作用。此外，来自ICAM-1缺陷小鼠的B细胞对FasL + T细胞介导的死亡具有抗性。我们的结果表明，LFA-1/ICAM相互作用对于Th1细胞介导的B细胞凋亡至关重要，并且可能有助于体内B细胞稳态的维持。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8a3/2199075/26dcadda8504/JEM.971069f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8a3/2199075/65c24e30e097/JEM.971069f1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8a3/2199075/d70f216eb440/JEM.971069f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8a3/2199075/26dcadda8504/JEM.971069f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8a3/2199075/65c24e30e097/JEM.971069f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8a3/2199075/ee249ebe9112/JEM.971069f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8a3/2199075/ed65f847c0a9/JEM.971069f3.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8a3/2199075/26dcadda8504/JEM.971069f6.jpg

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FLICE is activated by association with the CD95 death-inducing signaling complex (DISC).FLICE通过与CD95死亡诱导信号复合物（DISC）结合而被激活。
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