Pharmacology of 9-gamma-methylaminopropyl-9,10-dihydro-9,10-methanoanthracene-HCl (ID-9206-HCl), a new potent antidepressant.

The pharmacological properties of 9-gamma-methylaminopropyl-9,10-dihydro-9,10-methanoanthracene-HCl (ID-9206-HCl) were examined in comparison with those of imipramine, amitriptyline and maprotiline in animals. ID-9206 showed the characteristic pharmacological profile of an antidepressent: anti-reserpine and anti-tetrabenazine activities, potentiation of central and peripheral actions of norepinephrine, and potentiation of methamphetamine and yohimbine actions. ID-9206 had weak peripheral anticholinergic activities and sedative effects. ID-9206 was less toxic in mice and rats than the other three antidepressants.