白细胞葡萄糖6磷酸脱氢酶作为急性非淋巴细胞白血病和慢性粒细胞白血病的预后指标

Leukocyte glucose 6 phosphate dehydrogenase as prognostic indicator in ANLL and CML.

作者信息

Devi G S, Prasad M H, Reddy P P, Rao D N

机构信息

Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad, India.

出版信息

Indian J Exp Biol. 1997 Feb;35(2):155-8.

PMID:9315224

Abstract

Glucose 6 phosphate dehydrogenase (G6PD) was estimated in the leucocytes of 35 patients with acute non-lymphocytic leukemia (ANLL) and 10 patients with chronic myeloid leukemia (CML). G6PD levels were found to be significantly decreased in majority of the patients with ANLL while it was increased in all CML patients. Variation in G6PD was found to be dependent on the percentage of myelocytes inANLL. Cytogenetic analysis was also carried out in these patients. Correlation analysis of leucocyte G6PD activity and karyotype with prognostic assessment clearly indicated the association of (s) high percentage of chromosomal abnormalities especially translocations, (b) low survival and remission rates, with patients having decreased G6PD activity when compared to patients with normal activity in ANLL. The studies indicate that leucocyte G6PD may be useful as a diagnostic and prognostic tool.

摘要

对35例急性非淋巴细胞白血病（ANLL）患者和10例慢性粒细胞白血病（CML）患者的白细胞进行了葡萄糖6磷酸脱氢酶（G6PD）检测。结果发现，大多数ANLL患者的G6PD水平显著降低，而所有CML患者的G6PD水平均升高。ANLL患者的G6PD变化取决于髓细胞百分比。还对这些患者进行了细胞遗传学分析。白细胞G6PD活性和核型与预后评估的相关性分析清楚地表明，与ANLL中G6PD活性正常的患者相比，（a）染色体异常尤其是易位的高百分比、（b）低生存率和缓解率与G6PD活性降低的患者相关。研究表明，白细胞G6PD可能作为一种诊断和预后工具。