Kulkarni C, David J, Joseph T
Department of Pharmacology, St. John's Medical College, Bangalore, India.
Indian J Exp Biol. 1997 Apr;35(4):342-7.
The effects of adenosine (100 nM, icv), dipyridamole (DPM, 5 mg/kg, i.p.), adenosine A1 receptor antagonist 8-cyclopentyl-theophylline (8-CPT, 10 mg/kg, i.p.), and aminophylline (AMP) and caffeine (CAF) (at equivalent doses of 35 mg/kg, i.p.), were examined in rats. Anti-epileptic drugs (AEDs) were also administered i.p., viz, carbamazepine (CBZ, 10 mg/kg); phenobarbitone (PB, 10 mg/kg); phenytoin (PHT, 20 mg/kg); valproic acid (VPA, 300 mg/kg); and diazepam (DZP, 10 mg/kg), to study their effects on EEG after discharge (AD) and postictal depression (PID) induced by cortical stimulation. The AD parameters: (1) duration of EEG-AD (sec) and (2) number of spikes was noted both during pre and post drug treatment sessions. Adenosine and DPM had no special effects on AD parameters but showed significant prolongation of PID. All the adenosine antagonists, 8-CPT, AMP and CAF produced significant prolongation of AD duration, increase in number of spikes and reduced the duration of PID to a significant extent. Interestingly, some of the AEDs, viz. CBZ, VPA and DZP showed abolition of all the EEG-AD parameters whereas PB and PHT failed to show any significant effect. The results confirm previous findings on involvement of adenosine in postictal events.
在大鼠中研究了腺苷（100 nM，脑室内注射）、双嘧达莫（DPM，5 mg/kg，腹腔注射）、腺苷A1受体拮抗剂8-环戊基茶碱（8-CPT，10 mg/kg，腹腔注射）、氨茶碱（AMP）和咖啡因（CAF）（腹腔注射等效剂量为35 mg/kg）的作用。还腹腔注射了抗癫痫药物（AEDs），即卡马西平（CBZ，10 mg/kg）；苯巴比妥（PB，10 mg/kg）；苯妥英（PHT，20 mg/kg）；丙戊酸（VPA，300 mg/kg）；地西泮（DZP，10 mg/kg），以研究它们对皮层刺激诱导的放电后脑电图（AD）和发作后抑郁（PID）的影响。记录AD参数：（1）药物治疗前和治疗后的脑电图-AD持续时间（秒）和（2）棘波数量。腺苷和DPM对AD参数无特殊影响，但显示PID显著延长。所有腺苷拮抗剂，8-CPT、AMP和CAF均使AD持续时间显著延长，棘波数量增加，并在很大程度上缩短了PID的持续时间。有趣的是，一些AEDs，即CBZ、VPA和DZP可消除所有脑电图-AD参数，而PB和PHT未显示任何显著影响。结果证实了先前关于腺苷参与发作后事件的研究发现。
