Rowland D L, Myers L, Culver A, Davidson J M
Department of Psychology, Valparaiso University, IN 46383, USA.
J Clin Psychopharmacol. 1997 Oct;17(5):350-7. doi: 10.1097/00004714-199710000-00003.
Many antidepressant agents interfere with sexual function. The purpose of this single-blind, prospective study was to determine sexual side effects, both positive and negative, of the amino-ketone antidepressant bupropion in a group of nondepressed diabetic men with somatic erectile dysfunction. Fourteen men participated in a 10-week protocol consisting sequentially of 2 weeks of baseline testing, 2 weeks of placebo, and 6 weeks of bupropion. Participants also completed daily and weekly questionnaires concerning sexual functioning, and a team of investigators rated various dimensions of sexual function every 2 weeks. In addition, a variety of physiologic measures, relevant either to erectile function or to neural/vascular systems that underlie sexual response, were assessed during baseline and bupropion treatment. Results indicated that neither subjective nor objective measures of erectile and overall sexual functioning worsened during bupropion. In fact, several measures suggested a trend toward improved sexual functioning. Furthermore, diabetic control was unaffected by bupropion administration. Given the lack of adverse effects on sexual function, along with the potential for improved erectile response, bupropion may provide an attractive choice for the treatment of depression in diabetic men or others for whom sexual dysfunction is a concern.
许多抗抑郁药会干扰性功能。这项单盲前瞻性研究的目的是确定氨基酮类抗抑郁药安非他酮对一组患有躯体性勃起功能障碍的非抑郁糖尿病男性的性功能副作用，包括正面和负面的影响。14名男性参与了一项为期10周的方案，该方案依次包括2周的基线测试、2周的安慰剂治疗以及6周的安非他酮治疗。参与者还完成了关于性功能的每日和每周问卷，并且一组研究人员每2周对性功能的各个维度进行评分。此外，在基线和安非他酮治疗期间，评估了各种与勃起功能或性反应基础的神经/血管系统相关的生理指标。结果表明，在服用安非他酮期间，勃起功能和整体性功能的主观和客观指标均未恶化。事实上，多项指标显示出性功能有改善的趋势。此外，安非他酮的使用并未影响糖尿病的控制。鉴于其对性功能没有不良影响，以及有改善勃起反应的潜力，安非他酮可能为治疗糖尿病男性或其他担心性功能障碍的人群的抑郁症提供一个有吸引力的选择。
