Yarbrough D R
J S C Med Assoc. 1997 Sep;93(9):347-50.
The toxic epidermal necrolysis syndrome (TENS) is one of several clinically similar severe acute exfoliative skin disorders which have become of increasing interest to burn surgeons in recent years. Recognition of a clinical course similar to extensive second-degree burns has resulted in the development of treatment protocols which are best carried out in a burn unit by personnel experienced in critical care techniques, the management of major fluid and electrolyte derangements, the intensive nutritional support of critically ill patients, and the management of extensive cutaneous injuries with ready access to biologic wound dressings (homografts, xenografts). Current evidence suggests that TENS is a CD8 lymphocyte mediated reaction triggered by exposure to certain drugs in most instances. The target organs of the immune reaction are skin and mucus membranes. Treatment in burn units appears to have contributed significantly to the increasing survival of patients with this devastating and potentially lethal illness.
中毒性表皮坏死松解症（TENS）是几种临床症状相似的严重急性剥脱性皮肤病之一，近年来已引起烧伤外科医生越来越多的关注。认识到其临床病程与广泛的二度烧伤相似，促使人们制定了治疗方案，而这些方案最好在烧伤病房由具备重症护理技术、处理严重液体和电解质紊乱、为重症患者提供强化营养支持以及处理大面积皮肤损伤并能随时获取生物伤口敷料（同种异体移植物、异种移植物）经验的人员来实施。目前的证据表明，在大多数情况下，TENS是由接触某些药物引发的CD8淋巴细胞介导的反应。免疫反应的靶器官是皮肤和黏膜。在烧伤病房进行治疗似乎对这种毁灭性且可能致命疾病患者存活率的提高起到了显著作用。
