一氧化碳存在时人体血液的氧亲和力。

Oxygen affinity of human blood in presence of carbon monoxide.

作者信息

Collier C R

出版信息

J Appl Physiol. 1976 Mar;40(3):487-90. doi: 10.1152/jappl.1976.40.3.487.

DOI:10.1152/jappl.1976.40.3.487

Abstract

If carbon monoxide is present in the blood, it is necessary to quantitate its effect on apparent O2 affinity in order to properly compute venous PO2 and P50. Ways of doing this are analyzed theoretically. The classical principles of Haldane and of Roughton and Darling are reviewed and simplified. The method of computation of PO2 in the presence of CO as introduced by Forster is shown to be in considerable error. The source of this error is determined. The error produced if the presence of CO is ignored during the computation of P50 is analyzed.

摘要

如果血液中存在一氧化碳，有必要对其对表观氧亲和力的影响进行定量，以便正确计算静脉血氧分压（PO2）和P50。本文从理论上分析了实现这一目的的方法。对霍尔丹（Haldane）以及罗顿（Roughton）和达林（Darling）的经典原理进行了回顾和简化。结果表明，福斯特（Forster）引入的在一氧化碳存在情况下计算PO2的方法存在相当大的误差。确定了该误差的来源。分析了在计算P50时忽略一氧化碳存在所产生的误差。