Stewart R M, Hemli S, Daniels G H, Kolodny E H, Maloof F
J Clin Endocrinol Metab. 1976 Jun;42(6):1179-81. doi: 10.1210/jcem-42-6-1179.
Serum thyroxine and triiodothyronine levels in 15 adult phenylketonuric patients on an unrestricted diet were normal despite reduced circulating tyrosine levels. Serum thyrotropin levels were normal in the basal state or in response to thyrotropin-releasing hormone in selected patients tested. These results support and extend previous observations of normal thyroid function in phenylketonuria.
15名接受无限制饮食的成年苯丙酮尿症患者,尽管其循环酪氨酸水平降低,但血清甲状腺素和三碘甲状腺原氨酸水平正常。在基础状态下或在对部分受试患者给予促甲状腺激素释放激素后,血清促甲状腺激素水平正常。这些结果支持并拓展了先前关于苯丙酮尿症患者甲状腺功能正常的观察结果。