Coe J E, Cieplak W, Hadlow W J, Ross M J
Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840, USA.
Am J Physiol. 1997 Sep;273(3 Pt 2):R934-41. doi: 10.1152/ajpregu.1997.273.3.R934.
The Syrian hamster (Mesocricetus auratus) has been widely used as an experimental animal and is a unique model for three sex hormone-regulated events: 1) estrogen-initiated renal carcinogenesis, 2) sex-limited expression of amyloidosis, a ubiquitous disease, and 3) sex hormone control of a serum amyloid P component (SAP) called female protein (FP). In this study, we evaluated the closely related Turkish hamster (Mesocricetus brandti) for these three events and found some very different responses: 1) estrogen-initiated renal carcinogenesis was not found in Turkish hamster, 2) amyloidosis was not sex limited and actually was a rare disease in the Turkish hamster, and 3) Turkish hamsters did express a sex-limited SAP-FP in serum that was antigenically identical and structurally very similar (97.5%) to Syrian hamster SAP-FP. However, acute phase regulation of SAP-FP synthesis was different, and serum levels of this pentraxin were much lower than those found in the Syrian hamster. On the other hand, in contrast to findings in the Syrian hamster, hepatic tumors were relatively common in normal and especially in estrogen-treated Turkish hamsters. Therefore, although they are closely related, these two Mesocricetus hamster species have markedly dissimilar responses to sex hormones.
叙利亚仓鼠（金黄地鼠）已被广泛用作实验动物，是三种性激素调节事件的独特模型：1）雌激素引发的肾癌发生；2）淀粉样变性病（一种普遍存在的疾病）的性别限制表达；3）对一种称为雌性蛋白（FP）的血清淀粉样蛋白P成分（SAP）的性激素控制。在本研究中，我们评估了密切相关的土耳其仓鼠（布氏中仓鼠）的这三种事件，发现了一些非常不同的反应：1）在土耳其仓鼠中未发现雌激素引发的肾癌发生；2）淀粉样变性病无性别限制，实际上在土耳其仓鼠中是一种罕见疾病；3）土耳其仓鼠确实在血清中表达了一种性别限制的SAP-FP，其抗原性与叙利亚仓鼠的SAP-FP相同，结构非常相似（97.5%）。然而，SAP-FP合成的急性期调节不同，并且这种五聚体蛋白的血清水平远低于叙利亚仓鼠中的水平。另一方面，与叙利亚仓鼠的发现相反，肝肿瘤在正常的尤其是经雌激素处理的土耳其仓鼠中相对常见。因此，尽管这两种中仓鼠关系密切，但它们对性激素的反应明显不同。
