Coe J E, Ross M J
Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840.
Am J Physiol. 1990 Aug;259(2 Pt 2):R341-9. doi: 10.1152/ajpregu.1990.259.2.R341.
The serum of Armenian hamster (Cricetulus migratorius) contains a protein homologous to female protein (FP) that has been characterized in the Syrian (golden) hamster. Of unknown function, FP belongs to a family of proteins (called pentraxins) that have a common ancestral gene and are widely expressed in nature. Whereas serum concentration of FP in Syrian hamsters (SFP) is many fold greater (200- to 300-fold) in females vs. males, Armenian hamster FP (AFP) is only moderately elevated (approximately 3-fold) in female vs. males and only for the fall-winter months of the year. In the Armenian hamster testosterone administration to females or castration of males has no effect on AFP serum levels, whereas in Syrian hamster these treatments change SFP serum concentration to that characteristic of the opposite sex. Some sex steroid control of hepatic AFP synthesis is evident, however, as serum levels decrease after exogenous estrogen treatment. In contrast to Syrian hamster FP, normal levels of AFP are dependent on an intact hypophysial-pituitary axis and also are influenced by the season of the year. As an acute-phase protein, AFP responds in a typical fashion, with increasing serum levels detected in both sexes in contrast to the divergent sex-limited response in Syrian hamsters. Although AFP and SFP are similar structurally, morphologically, and antigenetically and share common binding specificities, the regulation of FP synthesis in Armenian hamster is very different from that previously found in Syrian hamster.
亚美尼亚仓鼠（黑线仓鼠）的血清中含有一种与叙利亚（金黄）仓鼠中已被鉴定的雌性蛋白（FP）同源的蛋白质。FP功能未知，属于一类蛋白质（称为五聚体蛋白），它们有一个共同的祖先基因，在自然界中广泛表达。叙利亚仓鼠血清中FP（SFP）的浓度在雌性中比雄性高许多倍（200至300倍），而亚美尼亚仓鼠的FP（AFP）在雌性中仅适度升高（约3倍），且仅在一年中的秋冬月份如此。在亚美尼亚仓鼠中，对雌性给予睾酮或对雄性进行阉割对AFP血清水平没有影响，而在叙利亚仓鼠中，这些处理会使SFP血清浓度变为异性的特征浓度。然而，由于外源性雌激素处理后血清水平降低，肝AFP合成存在一定的性类固醇控制。与叙利亚仓鼠FP不同，AFP的正常水平依赖于完整的下丘脑-垂体轴，并且也受一年中季节的影响。作为一种急性期蛋白，AFP以典型方式反应，两性血清水平均升高，这与叙利亚仓鼠中不同的性别限制反应形成对比。尽管AFP和SFP在结构、形态和抗原性上相似且具有共同的结合特异性，但亚美尼亚仓鼠中FP合成的调节与先前在叙利亚仓鼠中发现的调节非常不同。
