Deng Y, Seliskar C J, Heineman W R
Department of Chemistry, University of Cincinnati, Ohio 45221-0172, USA.
Anal Chem. 1997 Oct 1;69(19):4045-50. doi: 10.1021/ac961295v.
The perfluorosulfonated ionomer Nafion shows potential utility as a polymer film to enhance the electrochemical detection of [ReI(DMPE)3]+, where DMPE = 1,2-bis-(dimethylphosphino)ethane. [ReI(DMPE)3]+, a nonradioactive radiopharmaceutical analog for heart imaging, partitions strongly into Nafion films on glassy carbon. Well-defined, chemically reversible cyclic voltammograms are obtained for the [ReI(DMPE)3]+/[ReII(DMPE)3]2+ couple with Eo' shifted positively by 60 mV relative to its value on bare glassy carbon. [ReI(DMPE)3]+ partitions into Nafion more strongly than the oxidized form, [ReII-(DMPE)3]2+. The detection limit for [ReI(DMPE)3]+ by cyclic voltammetry was improved by 2-3 orders of magnitude by the Nafion film. Differential pulse voltammetry for oxidation of [ReI(DMPE)3]+ at the Nafion-modified electrode has a detection limit of 2.5 x 10(-9) M compared to 1.0 x 10(-7) M at the bare electrode. A preconcentration factor of 1 x 10(6) for partitioning of [ReI(DMPE)3]+ from 0.05 M NaCl into Nafion on a glassy carbon electrode was measured.
全氟磺酸离子聚合物Nafion作为一种聚合物薄膜，在增强[ReI(DMPE)3]+（其中DMPE = 1,2 - 双（二甲基膦基）乙烷）的电化学检测方面显示出潜在的应用价值。[ReI(DMPE)3]+是一种用于心脏成像的非放射性放射性药物类似物，它能强烈地分配到玻碳上的Nafion薄膜中。对于[ReI(DMPE)3]+/[ReII(DMPE)3]2+电对，相对于其在裸玻碳上的值，Eo'正向移动了60 mV，从而获得了明确的、化学可逆的循环伏安图。[ReI(DMPE)3]+比氧化形式[ReII-(DMPE)3]2+更强烈地分配到Nafion中。通过Nafion薄膜，循环伏安法对[ReI(DMPE)3]+的检测限提高了2 - 3个数量级。在Nafion修饰电极上，[ReI(DMPE)3]+氧化的差分脉冲伏安法检测限为2.5×10(-9) M，而在裸电极上为1.0×10(-7) M。测量了[ReI(DMPE)3]+从0.05 M NaCl分配到玻碳电极上的Nafion中的预富集因子为1×10(6)。
