Sgarabotto D, Vianello F, Radossi P, Poletti A, Sotti G, Stefani P M, Sartori R, Girolami A
Fourth Chair of Internal Medicine, Institute of Medical Semeiotics, University of Padua Medical School, Italy.
Leuk Lymphoma. 1997 Jul;26(3-4):395-8. doi: 10.3109/10428199709051790.
The therapeutic approach to hairy cell leukemia (HCL) is in some instances still debated. A variant form of HCL (HCL-V) characterized by high white cell count, splenomegaly, hypercellular and aspirable bone marrow has been described; differential diagnosis often arises with some other B-cell disorders which also show circulating hairy or villous lymphocytes. Conventional treatment for HCL is often less effective in HCL-V. In this report we describe a case with features consistent with HCL-variant treated with splenic radiotherapy. We not only obtained an hematological response but also the near total disappearance of bone marrow infiltration, compatible with a clinical complete remission. Clinical and biological implications of this phenomenon are discussed on the basis of this unexpected therapeutic result, obtained with splenic radiotherapy alone.
毛细胞白血病（HCL）的治疗方法在某些情况下仍存在争议。一种以高白细胞计数、脾肿大、骨髓细胞增多且可抽吸为特征的HCL变异型（HCL-V）已被描述；鉴别诊断常常与其他一些同样表现为循环中出现毛细胞或绒毛状淋巴细胞的B细胞疾病相混淆。HCL的传统治疗方法对HCL-V往往效果较差。在本报告中，我们描述了一例采用脾脏放疗治疗的具有HCL变异型特征的病例。我们不仅获得了血液学缓解，而且骨髓浸润几乎完全消失，符合临床完全缓解。基于仅通过脾脏放疗获得的这一意外治疗结果，我们讨论了这一现象的临床和生物学意义。
