Yasuda T, Sakata Y, Kitamura K, Morita M, Ishida T
Department of Otolaryngology, Jichi Medical School, Tochigi, Japan.
Head Neck. 1997 Oct;19(7):611-6. doi: 10.1002/(sici)1097-0347(199710)19:7<611::aid-hed8>3.0.co;2-a.
Plasminogen activators (PAs) and their inhibitors are thought to play an important role in tumor invasion and metastasis. However, there have been few reports in which histologic localization of PAs has been demonstrated in head and neck tumors.
We examined the patterns of expression of urokinase-type plasminogen activator (u-PA), tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor 1 (PAI-1), and vitronectin in head and neck squamous cell carcinomas using immunohistochemical techniques. We also studied the correlation between the immunohistologic expression of these fibrinolytic proteins and the clinical staging of the tumor.
Of 28 tumor specimens, 15 (54%) showed immunoreactivity for u-PA; 8 (36%), for t-PA; and 23 ( 82%), for PAI-1. There was a significant correlation between PAI-1 expression and the extent of the primary tumor.
The present study demonstrates the existence and possible pathophysiologic significance of u-PA and PAI-1 in squamous cell carcinomas of the head and neck.
纤溶酶原激活剂（PAs）及其抑制剂被认为在肿瘤侵袭和转移中起重要作用。然而，关于头颈部肿瘤中PA的组织学定位的报道很少。
我们使用免疫组织化学技术检测了头颈部鳞状细胞癌中尿激酶型纤溶酶原激活剂（u-PA）、组织型纤溶酶原激活剂（t-PA）、纤溶酶原激活剂抑制剂1（PAI-1）和玻连蛋白的表达模式。我们还研究了这些纤维蛋白溶解蛋白的免疫组织学表达与肿瘤临床分期之间的相关性。
在28个肿瘤标本中，15个（54%）对u-PA呈免疫反应；8个（36%）对t-PA呈免疫反应；23个（82%）对PAI-1呈免疫反应。PAI-1表达与原发肿瘤范围之间存在显著相关性。
本研究证明了u-PA和PAI-1在头颈部鳞状细胞癌中的存在及其可能的病理生理意义。
Zotero 插件