Papavasiliou F, Casellas R, Suh H, Qin X F, Besmer E, Pelanda R, Nemazee D, Rajewsky K, Nussenzweig M C
Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10021, USA.
Science. 1997 Oct 10;278(5336):298-301. doi: 10.1126/science.278.5336.298.
The clonal selection theory states that B lymphocytes producing high-affinity immunoglobulins are selected from a pool of cells undergoing antibody gene mutation. Somatic hypermutation is a well-documented mechanism for achieving diversification of immune responses in mature B cells. Antibody genes were also found to be modified in such cells in germinal centers by recombination of the variable (V), diversity (D), and joining (J) segments. The ability to alter immunoglobulin expression by V(D)J recombination in the selective environment of the germinal center may be an additional mechanism for inactivation or diversification of immune responses.
克隆选择理论指出，产生高亲和力免疫球蛋白的B淋巴细胞是从经历抗体基因突变的细胞池中筛选出来的。体细胞高频突变是成熟B细胞实现免疫反应多样化的一种充分记录的机制。在生发中心的此类细胞中，还发现抗体基因通过可变（V）、多样（D）和连接（J）片段的重组而发生修饰。在生发中心的选择性环境中通过V（D）J重组改变免疫球蛋白表达的能力可能是免疫反应失活或多样化的另一种机制。
