接受血液透析和持续性非卧床腹膜透析的儿童的重组人促红细胞生成素剂量

Recombinant human erythropoietin dosage in children undergoing hemodialysis and continuous ambulatory peritoneal dialysis.

作者信息

Sieniawska M, Roszkowska-Blaim M

机构信息

Department of Pediatrics and Nephrology, University Children's Hospital, Warsaw, Poland.

出版信息

Pediatr Nephrol. 1997 Oct;11(5):628-30. doi: 10.1007/s004670050352.

DOI:10.1007/s004670050352

PMID:9323294

Abstract

The efficacy of erythropoietin (EPO) in 11 children on hemodialysis (HD) and 8 on continuous ambulatory peritoneal dialysis (CAPD) (mean age 11.8 years) was compared. The initial EPO dose was 50 U/kg s.c. once a week; the time of observation was 24 weeks. In the CAPD group, the mean hemoglobin (Hb) level increased from 7.7 +/- 0.2 to 11.2 +/- 0.6 g/dl (P < 0.001) and hematocrit (Hct) from 22.3 +/- 1.0 to 32.6 +/- 1.4% (P < 0.001), while in the HD group the mean Hb rose from 7.7 +/- 0.6 to 9.3 +/- 0.8 g/dl (P < 0.001) and mean Hct from 22.7 +/- 2.3 to 27.6 +/- 2.8% (P < 0.001) after 12 weeks of observation. An increase in Hb to over 10 g/dl was obtained in 87.5% of children on CAPD but in only 10% on HD after 8 weeks of EPO treatment. After 12 weeks of treatment, all children on CAPD had the target Hb level of more than 10 g/dl, while 7 children on HD required increased doses of EPO (100 U/kg per week). We conclude that the EPO dose of 50 u/kg given s.c. once a week is effective for children with anemia on CAPD but is insufficient for children on HD.

摘要

比较了促红细胞生成素（EPO）对11名接受血液透析（HD）的儿童和8名接受持续性非卧床腹膜透析（CAPD）的儿童（平均年龄11.8岁）的疗效。初始EPO剂量为每周一次皮下注射50 U/kg；观察时间为24周。在CAPD组中，平均血红蛋白（Hb）水平从7.7±0.2 g/dl升至11.2±0.6 g/dl（P<0.001），血细胞比容（Hct）从22.3±1.0%升至32.6±1.4%（P<0.001），而在HD组中，观察12周后，平均Hb从7.7±0.6 g/dl升至9.3±0.8 g/dl（P<0.001），平均Hct从22.7±2.3%升至27.6±2.8%（P<0.001）。EPO治疗8周后，87.5%接受CAPD的儿童Hb升至超过10 g/dl，但接受HD的儿童中只有10%达到此水平。治疗12周后，所有接受CAPD的儿童Hb水平均达到目标值超过10 g/dl，而7名接受HD的儿童需要增加EPO剂量（每周100 U/kg）。我们得出结论，每周一次皮下注射50 u/kg的EPO剂量对CAPD贫血儿童有效，但对HD儿童不足。