[Diffusion of cefuroxime into the prostatic and other tissues of the urogenital region (author's transl)].

From 33 patients with prostatic adenoma with an average age of 68.4 years, serum and prostatic tissue concentrations after a single bolus-dose of 1.5 grams of cefuroxime were estimated. The mean serum concentrations 30 to 35 minutes after the injection were measured with 132.6 and after 55 to 60 minutes with 99.6 micrograms/ml. The corresponding concentrations in the prostata tissue were 29.2 after 30 to 35 minutes and 20.1 micrograms/g after 55 to 60 minutes respectively. After 145 to 155 minutes the concentrations in the serum were still at 23 micrograms/ml and 9.2 micrograms/g in the prostatic tissue. In other organ tissues of the urogenital region (renal tissue, testicle, fat, muscle) the concentrations were different depending on the state of the tissue. The estimated concentrations of cefuroxime in serum and tissue are suited for the treatment of infections caused by cefuroxime sensitive microorganisms.