Ziganshin A U, Ziganshina L E, Burnstok D Zh
University College London, UK.
Eksp Klin Farmakol. 1997 May-Jun;60(3):78-82.
Although enzymes which metabolize extracellular ATP (ecto-ATPases) have been described long ago, it has only recently become clear that such enzymes play an especially important role in cells possessing ATP receptors (P2-purinoceptors). In this review the authors characterize common features of ecto-ATPases, underlining the differences between these enzymes and other ATP-metabolizing enzymes. The authors also review their own recent studies dealing with the effects of various compounds on enzyme activity and on P2-purinoceptor-mediating responses. Since most known P2-purinoceptor antagonists inhibit ecto-ATPase activity, it is important to search for selective P2-purinoceptor antagonists as well as ecto-ATPase inhibitors.
虽然很久以前就已描述了代谢细胞外ATP的酶（胞外ATP酶），但直到最近才清楚地认识到，这类酶在具有ATP受体（P2嘌呤能受体）的细胞中发挥着尤为重要的作用。在这篇综述中，作者阐述了胞外ATP酶的共同特征，强调了这些酶与其他ATP代谢酶之间的差异。作者还回顾了他们自己最近的研究，这些研究涉及各种化合物对酶活性以及对P2嘌呤能受体介导反应的影响。由于大多数已知的P2嘌呤能受体拮抗剂会抑制胞外ATP酶的活性，因此寻找选择性P2嘌呤能受体拮抗剂以及胞外ATP酶抑制剂很重要。
