Olze H, Kaschke O, Müller W D
Hals-Nasen-Ohren-Klinik, Universitätsklinikum Charité Berlin.
HNO. 1997 Jun;45(6):453-9. doi: 10.1007/s001060050123.
Replacement of the tracheal conduit remains an unresolved problem. The microporous material expanded polytetrafluorethylene (ePTFE) is suitable for tracheal reconstruction. The aim of our study was to improve the limited mechanical properties of this material by incorporating reinforcement elements and to examine the influence of these elements on host incorporation and epithelialization. In so dours ePTFE prostheses were reinforced with lonomer cement and porous high density polyethylene (pHDPE) rings and implanted into the neck muscle of miniature pigs. One of these prostheses was epithelialized by a cell seeding technique and was thus placed into a tracheal defect. Results were examined grossly by endoscopy and than by light and scanning electron microscopy. The shapes of both types of prostheses showed a high stability. The reinforcement elements did not impair bioincorporation or the ability to epithelialize. In vivo interposition of an incorporated and epithelialized prosthesis to a host led to cell differentiation. The improved biomechanical properties of the prostheses waid and the reproducible formation of epitheliums are important advances in the solution of effectively correcting tracheal defects.
气管导管的置换仍然是一个未解决的问题。微孔材料膨体聚四氟乙烯（ePTFE）适用于气管重建。我们研究的目的是通过加入增强元件来改善这种材料有限的力学性能，并研究这些元件对宿主整合和上皮化的影响。在这项研究中，ePTFE假体用离聚物水泥和多孔高密度聚乙烯（pHDPE）环增强，并植入小型猪的颈部肌肉。其中一个假体通过细胞接种技术实现上皮化，因此被放入气管缺损处。通过内窥镜进行大体检查，然后通过光镜和扫描电子显微镜检查结果。两种类型的假体形状都显示出很高的稳定性。增强元件不会损害生物整合或上皮化能力。将已整合并上皮化的假体在体内植入宿主体内会导致细胞分化。假体改善的生物力学性能以及上皮的可重复形成是有效纠正气管缺损解决方案中的重要进展。
