Reeck U H, Egerer G, Otto G, Hoffmann W, Arnold J C, Theilmann L, Conradt C, Herfarth C, Seitz H K
Abt. IV, Pathologisches Institut, Universität Heidelberg.
Rehabilitation (Stuttg). 1997 May;36(2):116-20.
Alcoholic liver cirrhosis is the main indication for orthotopic liver transplantation. Since 1988, 52 patients with alcoholic liver cirrhosis have been transplanted at the Department of Surgery of the University of Heidelberg. The survival rates are as follows: 73% of the patients survived for 1 year, 68% for 2 and 3 years, 64% for 4 years, and 57% survived for 5 years. After transplantation, recidivism occurred in 6 patients. Remarkable in this case was the fact that all 6 patients had a relatively short period of abstention prior to surgery (2 to 5 months). In 12 patients, a small carcinoma was found in the cirrhotic liver. This had neither been seen previously by ultrasound nor by computer tomography. In summary, orthotopic liver transplantation is an excellent mode of treatment in end-stage alcoholic liver cirrhosis. However, the patients have to be carefully selected in order to avoid recidivism following transplantation.
酒精性肝硬化是原位肝移植的主要适应证。自1988年以来，海德堡大学外科已为52例酒精性肝硬化患者实施了肝移植手术。生存率如下：73%的患者存活1年，68%存活2年和3年，64%存活4年，57%存活5年。移植后，6例患者复发。值得注意的是，这6例患者术前戒酒时间均相对较短（2至5个月）。12例患者在肝硬化肝脏中发现了小癌灶，此前超声和计算机断层扫描均未发现。总之，原位肝移植是终末期酒精性肝硬化的一种极佳治疗方式。然而，必须仔细挑选患者，以避免移植后复发。
