大鼠滋养层细胞系的免疫遗传和致癌特性。
Immunogenetic and oncogenic properties of rat trophoblast cell lines.
作者信息
Kunz H W, Yuan X J, Salgar S K, Dixon-McCarthy B, Gill T J
机构信息
Department of Pathology, University of Pittsburgh School of Medicine, PA 15261, USA.
出版信息
Am J Reprod Immunol. 1997 Sep;38(3):158-61. doi: 10.1111/j.1600-0897.1997.tb00292.x.
PROBLEM
The nature of major histocompatibility complex (MHC) antigen expression on rat placentas, trophoblast cell lines, and tumors derived from trophoblast cells was explored.
METHOD OF STUDY
Cytohistochemical and flow cytometric analysis and molecular techniques.
RESULTS
MHC antigen expression and genomic imprinting on the placenta and on trophoblast cells varies with the time of gestation and with the type of MHC antigen.
CONCLUSIONS
There is no correlation in trophoblast cells between class I expression and cell ploidy, on the one hand, and malignant potential, on the other hand. Genomic imprinting of class I antigens in the rat placenta is a quantitative phenomenon.
问题
探讨了大鼠胎盘、滋养层细胞系以及源自滋养层细胞的肿瘤上主要组织相容性复合体（MHC）抗原表达的性质。
研究方法
细胞组织化学和流式细胞术分析以及分子技术。
结果
胎盘和滋养层细胞上的MHC抗原表达及基因组印记随妊娠时间和MHC抗原类型而变化。
结论
一方面，滋养层细胞中I类表达与细胞倍性之间，另一方面与恶性潜能之间均无相关性。大鼠胎盘中I类抗原的基因组印记是一种定量现象。
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