Askin D F
St. Boniface General Hospital, Winnipeg, Manitoba, Canada.
Neonatal Netw. 1997 Aug;16(5):17-21.
Accurate interpretation of blood gases is paramount in clinical management in the NICU. This interpretation should be based on a sound understanding of acid-base physiology. Acid-base homeostasis depends on a series of complex chemical reactions controlled by the kidneys and the lungs. The maintenance of a blood pH within the narrow range required for normal cellular reactions requires a balance between acid production and excretion. Somewhat separate but equally important to blood gas interpretation is an understanding of oxygen transport. Included in this is the relationship between oxygen and hemoglobin. This article, the first in a two-part series, discusses the physiology of acid-base balance and oxygen transportation. The second article provides an approach for systematic interpretation of blood gases.
在新生儿重症监护病房（NICU）的临床管理中，准确解读血气至关重要。这种解读应基于对酸碱生理学的扎实理解。酸碱平衡依赖于由肾脏和肺控制的一系列复杂化学反应。要将血液pH维持在正常细胞反应所需的狭窄范围内，需要在酸的产生和排泄之间保持平衡。对血气解读而言，虽与酸碱平衡有所不同但同样重要的是对氧运输的理解。这其中包括氧气与血红蛋白之间的关系。本文是系列文章的第一篇，讨论酸碱平衡和氧运输的生理学。第二篇文章将提供一种系统解读血气的方法。
